Know that the BNP levels need to be assessed based on the patient’s age.Are you sure it’s bronchiolitis? Is that liver enlarged? Clinical concern for CHF? Check a BNP.NT-proBNP might be an adjunctive marker for hyper-acute phase of Kawasaki Disease.NT-proBNP measurements are not affected by different assays though. BNP levels need to be assessed based on specific commercial assay (cannot compare different assays’ levels).BNP / NT-proBNP levels can also be used to evaluate patients with known heart failure and monitor the effectiveness of therapies and need for surgery.Increase the accuracy of neonatal screening for Congenital Heart Disease.Improves the diagnostic accuracy in the evaluation of heart disease in children.BNP / NT-proBNP levels, in the clinical setting of suspicion for possible heart failure, have been shown to be valuable.After puberty, levels can increase toward adult levels and are higher in females than males. ĭiagnosis of newly developed heart failure in children is very challenging as it often initially presents with subtle and non-specific findings.From 1 month of age to ~12 years of age, BNP levels remain relatively stable in healthy individuals.Levels fall throughout first month of life.Additionally, kidneys are more immature and after load increases.Potentially to help with natriuresis and reduction of pulmonary vascular resistance.Levels are most elevated in the first 3-4 days of life:.Below the discriminatory level, the presentation is not likely related to cardiovascular etiology ( thus, more likely related to something like Bronchiolitis).Older infants and children (up to 19 years) – cutoff of 41 pg/mL (Sen- 87% Spec- 70%).
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